Ideas take shape to cure many diseases
Dynamics of IDO
URSULA GROHMANN (Principal Investigator)
Ursula Grohmann, Ph.D. in Experimental Medicine, has been working at the
Pharmacology Section of the Department of Experimental Medicine (DEM; University
of Perugia, Italy) since 1986, first as post-doc fellow, then as senior researcher and
associate professor. Since 2006, she has been appointed as full professor of
Pharmacology at DEM, University of Perugia, and, since July 2014, as Visiting
Professor at the Albert Einstein College of Medicine, New York, NY. In 1987-88 and
1990, she accomplished part of her research project (mainly based on tumor
immunology at that time) at the National Cancer Institute, National Institutes of
ANTONIO MACCHIARULO (Team Member)
Antonio Macchiarulo, received his doctorate in Chemistry and Technology of Drugs
in 2004, from the University of Perugia. He was then awarded with a Marie Curie
postdoctoral fellowship at the European Bioinformatics Institute in Cambridge (UK),
where he worked on selectivity and competition of substrate recognition by enzymes
with Irilenia Nobeli and Janet Thornton (Nat Biotechnol. 2004, 1039-45). Antonio
Macchiarulo is actually appointed as Associate Professor in Medicinal Chemistry at
the Department of Pharmaceutical Sciences of the University of Perugia. He is author
of over 100 papers (including two Nature Biotechnology and one Nature...........
Francesca Fallarino, PhD in experimental Medicine, is Associate Professor at the
University of Perugia. Her research is focused on the characterization of the
molecular mechanisms that regulate tolerance in the immune system. In
particular, she has contributed to the subject of immune tolerance, showing
evidence that tryptophan catabolism in tolerogenic dendritic cells (DCs) ........
Maura Marinozzi, PhD in Medicinal Chemistry, is Associate Professor at the Department
of Pharmaceutical Sciences of the University of Perugia. Her research activities include
the design and synthesis of steroidal and non-steroidal modulators of metabolic nuclear
receptors, and modulators of the kynurenine pathway of tryptophan metabolism, the
development of innovative synthetic methodologies based on on diazo-compounds, and
the development of more environmentally-friendly synthetic strategies ........
Ciriana Orabona, PhD in Experimental Medicine, is Researcher at the Pharmacology
Section of the Department of Experimental Medicine, University of Perugia (Italy). She
performed a part of her PhD (1998-2000) at the Ludwig Institute for Cancer Research
in Brussels. She was awarded in 2005 by Farmindustria for the best pharmacologic
research article of 2004 (Nat Immunol, 5(11):1134-42, 2004). She has been the
Principal Investigator (2011-2014) of a 3-yr grant from .........
MARIA LAURA BELLADONNA
Maria Laura Belladonna, PhD in Experimental Medicine, is Researcher at the
Pharmacology Section of the Department of Experimental Medicine, University of
Perugia (Italy). She performed postdoctoral studies at the Ludwig Institute for Cancer
Research in Brussels in 2001-2002. Dr. Belladonna’s research field deals with the study
of dendritic cell functions, cytokines linked to immunological mechanisms driven by
these cells (in particular IL-12, IL-23, and IL-35)........
Claudia Volpi, graduated in Pharmaceutical Chemistry and Technologies in 2002
(University of Perugia, Italy). During the PhD in Biology and Experimental Medicine
(University of Perugia), she explored intracellular molecular pathways activated by
glucocorticoids in plasmacytoid dendritic cells (pDCs)........
MARIA TERESA PALLOTTA
Maria Teresa Pallotta, PhD in Biology and Experimental Medicine (University of
Perugia), is now staff researcher at the Department of Experimental Medicine,
Pharmacology Section, University of Perugia. She graduated Magna Cum Laude in
Pharmaceutical Chemistry and Technologies in 2005 with a degree thesis focused on
the effects of the kynurenine pathway enzymes in immune tolerance........
Alberta Iacono graduated in Pharmaceutical Chemistry and Technology at the
University of Perugia in 2013 with a thesis entitled: “TGF-β: a long-term modulator in
immune tolerance” that deals with the role of the tryptophan catabolizing enzyme
indoleamine 2,3-dioxygenase (IDO) in response to the immunoregulatory cytokine TGF-
β. In particular, she focused her studies on IDO as signaling protein being fundamental
in mechanisms of long-term immune tolerance.........
Alice Coletti graduated in Pharmaceutical Chemistry and Technology at the University
of Perugia in 2013 with a thesis entitled: “ Design of peptides as modulators of
MDM2/MDM4 complex for the development of novel therapeutic agents in cancer
disease.” During her thesis internship, she started a collaboration with the National
Council of Research group led by Dr. Fabiola Moretti and focused her interest in protein-
protein and protein-peptide interactions........
FRANCESCO A. GRECO
Francesco A. Greco graduated in Pharmaceutical Chemistry and Technology at the
University of Perugia in 2014, discussing an experimental thesis on IDO1 modulators.
Along his educational course, he showed interest in many subjects, particularly in
pharmacology, drug discovery and rational drug design. In his master thesis, he worked
on the generation and analysis of a database containing molecules studied as IDO
inhibitors and he .............
Carmine Vacca graduated in Biology in 1989 at the University of Perugia. In 1994, he
got the PhD in Veterinarian Physiology and Biochemistry and, in 1999, was invited by
Prof. Maria Cristina Fioretti to join her group. Since then, he has continuously worked
for the Pharmacology Section at the Department of Experimental Medicine, with Prof.
Paolo Puccetti as mentor. With the other members of the Pharmacology group, he
discovered a crucial immunosuppressive role in tumor immunity............
Marco Gargaro graduated in Pharmaceutical Biotechnology at the University of Perugia
in 2012, discussing a thesis on the role of IDO1 in immune tolerance to exogenous
FVIII. Afterwords, he won a fellowship that allowed him to get further insights into
immune responses developed against exogenous FVIII administered as replacement
therapy in hemophilia A patients. Recently, he was involved in the role of the Aryl
Giada Mondanelli graduated in Pharmaceutical Chemistry and Technology at University
of Perugia in 2012, discussing a thesis on the role of the aryl hydrocarbon receptor in
endotoxic shock. Her thesis obtained an award for the best thesis in molecular biology
provided by the Anatomical-Surgical Academy, University of Perugia. Immediately after
graduation, she was selected for a six-month internship trainee at the drug-discovery
company TES Pharma, where she had the opportunity ........................
Roberta Bianchi graduated in Pharmacy at University of Perugia in 1977. She
performed her postdoctoral training at the University of Perugia from 1977 to 1986, as
recipient of a fellowship from the National Research Council. In 1986, she obtained the
position of graduated technician at the Department of Experimental Medicine and
Biochemical Sciences (University of Perugia). ........................
In over 30 years of research activity in the field of anti-infectious and antitumor
immunotherapy, including work in Dr. Herberman's Laboratory of Immunodiagnosis at
NIH (USA), Prof. Paolo Puccetti has contributed more than 230 published articles
appearing in the MEDLINE database. Research and professional experience include:
1974-80: Research Fellow (University of Perugia); 1976-77: Research Fellow
(Laboratory of Immunodiagnosis, NCI, NIH, USA) . ........................
Gianluca Andrielli is an Administrative Assistant and Technician at the Pharmacology
Section of the Dept. Experimental Medicine (University of Perugia) since 1991. He is in
charge of administrative and accounting requirements relating to revenue and
expenditure of the DIDO project. He is the designer and producer of all images
(including Figures for published papers) resulting from DIDO and other projects of the
Pharmacology Section, including websites. He has a reference role in the installment of
new instruments and setting of new laboratories.
Alessandra Giansanti is Deputy secretary of the Administrative Department of
Pharmaceutical Sciences at the University of Perugia. She is in charge of administrative
and accounting requirements relating to revenue and expenditure of the Department
and the organization and performance of all accounting, administrative and tax-related
activity institutional and commercial department. She takes care of the administrative
issues related to DIDO ERC Ideas Advanced Grant
Ioana-Maria Iamandii is performing the management and statistical analysis of
scientific data arising from and related to the ERC DIDO Grant as Project Assistant. She
graduated with a bachelor’s degree in Business Administration at Transilvania University
of Brasov (Romania) in 2012, and shortly after she began working on her master’s
degree in Management and Business Strategy (2014) at the same university. She also
studied and worked in the framework of an Erasmus LLP internship at the University of
Perugia during 2011-2012 and 2013.