Ideas take shape to cure many diseases
Dynamics of IDO
URSULA GROHMANN (Principal Investigator)  Ursula Grohmann, Ph.D. in Experimental Medicine, has been working at the  Pharmacology Section of the Department of Experimental Medicine (DEM; University  of Perugia, Italy) since 1986, first as post-doc fellow, then as senior researcher and  associate professor. Since 2006, she has been appointed as full professor of  Pharmacology at DEM, University of Perugia, and, since July 2014, as Visiting  Professor at the Albert Einstein College of Medicine, New York, NY. In 1987-88 and  1990, she accomplished part of her research project (mainly based on tumor  immunology at that time) at the National Cancer Institute, National Institutes of  Health, Bethesda,.......... 
Read all....
ANTONIO MACCHIARULO (Team Member)  Antonio Macchiarulo, received his doctorate in Chemistry and Technology of Drugs  in 2004, from the University of Perugia. He was then awarded with a Marie Curie  postdoctoral fellowship at the European Bioinformatics Institute in Cambridge (UK),  where he worked on selectivity and competition of substrate recognition by enzymes  with Irilenia Nobeli and Janet Thornton (Nat Biotechnol. 2004, 1039-45). Antonio  Macchiarulo is actually appointed as Associate Professor in Medicinal Chemistry at  the Department of Pharmaceutical Sciences of the University of Perugia. He is author  of over 100 papers (including two Nature Biotechnology and one Nature........... 
Read all.... Home People Infrastructure Collaborations Publications Other publications Photo gallery Contacts News
FRANCESCA FALLARINO  Francesca Fallarino, PhD in experimental Medicine, is Associate Professor at the  University of Perugia. Her research is focused on the characterization of the  molecular mechanisms that regulate tolerance in the immune system. In  particular, she has contributed to the subject of immune tolerance, showing  evidence that tryptophan catabolism in tolerogenic dendritic cells (DCs) ........ 
Read all.... Read all....
MAURA MARINOZZI  Maura Marinozzi, PhD in Medicinal Chemistry, is Associate Professor at the Department  of Pharmaceutical Sciences of the University of Perugia. Her research activities include  the design and synthesis of steroidal and non-steroidal modulators of metabolic nuclear  receptors, and modulators of the kynurenine pathway of tryptophan metabolism, the  development of innovative synthetic methodologies based on on diazo-compounds, and  the development of more environmentally-friendly synthetic strategies ........ 
Read all....
CIRIANA ORABONA  Ciriana Orabona, PhD in Experimental Medicine, is Researcher at the Pharmacology  Section of the Department of Experimental Medicine, University of Perugia (Italy). She  performed a part of her PhD (1998-2000) at the Ludwig Institute for Cancer Research  in Brussels.  She was awarded in 2005 by Farmindustria for the best pharmacologic  research article of 2004 (Nat Immunol, 5(11):1134-42, 2004). She has been the  Principal Investigator (2011-2014) of a 3-yr grant from .........  
Read all....
 MARIA LAURA BELLADONNA  Maria Laura Belladonna, PhD in Experimental Medicine, is Researcher at the  Pharmacology Section of the Department of Experimental Medicine, University of  Perugia (Italy). She performed postdoctoral studies at the Ludwig Institute for Cancer  Research in Brussels in 2001-2002. Dr. Belladonna’s research field deals with the study  of dendritic cell functions, cytokines linked to immunological mechanisms driven by  these cells (in particular IL-12, IL-23, and IL-35)........ 
CLAUDIA VOLPI Claudia Volpi, graduated in Pharmaceutical Chemistry and Technologies in 2002  (University of Perugia, Italy). During the PhD in Biology and Experimental Medicine  (University of Perugia), she explored intracellular molecular pathways activated by  glucocorticoids in plasmacytoid dendritic cells (pDCs)........ 
MARIA TERESA PALLOTTA  Maria Teresa Pallotta, PhD in Biology and Experimental Medicine (University of  Perugia), is now staff researcher at the Department of Experimental Medicine,  Pharmacology Section, University of Perugia. She graduated Magna Cum Laude in  Pharmaceutical Chemistry and Technologies in 2005 with a degree thesis focused on  the effects of the kynurenine pathway enzymes in immune tolerance........ 
ALBERTA IACONO  Alberta Iacono graduated in Pharmaceutical Chemistry and Technology at the  University of Perugia in 2013 with a thesis entitled: “TGF-β: a long-term modulator in  immune tolerance” that deals with the role of the tryptophan catabolizing enzyme  indoleamine 2,3-dioxygenase (IDO) in response to the immunoregulatory cytokine TGF-  β. In particular, she focused her studies on IDO as signaling protein being fundamental  in mechanisms of long-term immune tolerance......... 
Read all.... Read all.... Read all....
ALICE COLETTI  Alice Coletti  graduated in Pharmaceutical Chemistry and Technology at the University  of Perugia in 2013 with a thesis entitled: “ Design of peptides as modulators of  MDM2/MDM4 complex for the development of novel therapeutic agents in cancer  disease.” During her thesis internship, she started a collaboration with the National  Council of Research group led by Dr. Fabiola Moretti and focused her interest in protein-  protein and protein-peptide interactions........ 
Read all....
FRANCESCO A. GRECO  Francesco A. Greco graduated in Pharmaceutical Chemistry and Technology at the   University of Perugia in 2014, discussing an experimental thesis on IDO1 modulators.  Along his educational course, he showed interest in many subjects, particularly in  pharmacology, drug discovery and rational drug design. In his master thesis, he worked  on the generation and analysis of a database containing molecules studied as IDO  inhibitors and he ............. 
Read all....
CARMINE VACCA  Carmine Vacca graduated in Biology in 1989 at the University of Perugia. In 1994, he  got the PhD in Veterinarian Physiology and Biochemistry and, in 1999, was invited by  Prof. Maria Cristina Fioretti to join her group. Since then, he has continuously worked  for the Pharmacology Section at the Department of Experimental Medicine, with Prof.  Paolo Puccetti as mentor. With the other members of the Pharmacology group, he  discovered a crucial immunosuppressive role in tumor immunity............  
Read all....
MARCO GARGARO  Marco Gargaro graduated in Pharmaceutical Biotechnology at the University of Perugia  in 2012, discussing a thesis on the role of IDO1 in immune tolerance to exogenous  FVIII. Afterwords, he won a fellowship that allowed him to get further insights into  immune responses developed against exogenous FVIII administered as replacement  therapy in hemophilia A patients. Recently, he was involved in the role of the Aryl  hydrocarbon ........................ 
Read all....
GIADA MONDANELLI  Giada Mondanelli graduated in Pharmaceutical Chemistry and Technology at University  of Perugia in 2012, discussing a thesis on the role of the aryl hydrocarbon receptor in  endotoxic shock. Her thesis obtained an award for the best thesis in molecular biology  provided by the Anatomical-Surgical Academy, University of Perugia. Immediately after  graduation, she was selected for a six-month internship trainee at the drug-discovery  company TES Pharma, where she had the opportunity ........................ 
Read all....
ROBERTA BIANCHI  Roberta Bianchi graduated in Pharmacy at University of Perugia in 1977. She  performed her postdoctoral training at the University of Perugia from 1977 to 1986, as  recipient of a fellowship from the National Research Council. In 1986, she obtained the  position of graduated technician at the Department of Experimental Medicine and  Biochemical Sciences (University of Perugia). ........................ 
Read all....
PAOLO PUCCETTI  In over 30 years of research activity in the field of anti-infectious and antitumor  immunotherapy, including work in Dr. Herberman's Laboratory of Immunodiagnosis at  NIH (USA), Prof. Paolo Puccetti has contributed more than 230 published articles  appearing in the MEDLINE database. Research and professional experience include:  1974-80: Research Fellow (University of Perugia); 1976-77: Research Fellow  (Laboratory of Immunodiagnosis, NCI, NIH, USA) . ........................ 
Read all....
GIANLUCA ANDRIELLI Gianluca Andrielli is an Administrative Assistant and Technician at the Pharmacology  Section of the Dept. Experimental Medicine (University of Perugia) since 1991. He is in  charge of administrative and accounting requirements relating to revenue and  expenditure of the DIDO project. He is the designer and producer of all images  (including Figures for published papers) resulting from DIDO and other projects of the  Pharmacology Section, including websites. He has a reference role in the installment of  new instruments and setting of new laboratories.
ALESSANDRA GIANSANTI Alessandra Giansanti is Deputy secretary of the Administrative Department of  Pharmaceutical Sciences at the University of Perugia. She is in charge of administrative  and accounting requirements relating to revenue and expenditure of the Department  and the organization and performance of all accounting, administrative and tax-related  activity institutional and commercial department.  She takes care of the administrative  issues related to DIDO ERC Ideas Advanced Grant
IOANNA-MARIA IAMANDII Ioana-Maria Iamandii is performing the management and statistical analysis of  scientific data arising from and related to the ERC DIDO Grant as Project Assistant. She  graduated with a bachelor’s degree in Business Administration at Transilvania University of Brasov (Romania) in 2012, and shortly after she began working on her master’s  degree in Management and Business Strategy (2014) at the same university. She also  studied and worked in the framework of an Erasmus LLP internship at the University of  Perugia during 2011-2012 and 2013.
Top
People